39: Salicylates
نویسنده
چکیده
The Ancient Egyptians recognized the pain-relieving effects of concoctions made from myrtle and willow leaves. Hippocrates may have been among the first to use willow bark and leaves from the Salix species to relieve fever, but it was not until 1829 that the glycoside salicin was extracted from the willow bark and used as an antipyretic. Seven years later, salicylic acid was isolated, and by the late 1800s, it was being used to treat gout, rheumatic fever, and elevated temperatures. The less irritating acetylated salicylate compound was first synthesized in 1833, and in 1899 acetylsalicylic acid was commercially introduced as aspirin by Bayer. With that, the modern era of aspirin therapy and salicylate toxicity began.
منابع مشابه
Antipyretic Activity and Acute Toxicity of Phosphorous Containing Salicylates
New phosphorous-containing salicylates and two allyl salicylates with pharmacological potential, derived from salicylic acid, have been synthesized. Their chemical structure has been established by spectral analyses (mass spectra and 1H-NMR). The salicylates presented low toxicity, also showing a remarkable antipyretic activity, greater than that of acetylsalicylic acid (aspirin). Partition coe...
متن کاملNew steroids and new salicylates in inflammatory bowel disease: a critical appraisal.
Although new salicylates are now available for the treatment of ulcerative colitis, sulphasazaline still has an important therapeutic role. The role of salicylates in Crohn's disease is limited to the mild activity phase; further data are required to clarify its role in maintenance on remission. New steroids are a real alternative to traditional steroids in active ulcerative colitis and Crohn's...
متن کاملMetabolic acidosis induced by carbonic anhydrase inhibitors and salicylates in patients with normal renal function.
Two young patients with unimpaired renal and hepatic function were found to have developed metabolic acidosis after treatment for glaucoma and joint pain with a combination of salicylates and carbonic anhydrase inhibitors in normal doses. Carbonic anhydrase inhibitors appear to interact with salicylates to produce serious metabolic acidosis in patients without the predisposing factors generally...
متن کاملDifferent effects of inhaled aspirinlike drugs on allergen-induced early and late asthmatic responses.
Little is known about the anti-asthmatic effects of powerful anti-inflammatory agents such as aspirin-like drugs. We compared the effects of two aspirin-like drugs with different pharmacologic activities, sodium salicylate (SSA) and indomethacin, with the effect of lysine acetylsalicylate (LASA), inhaled 30 min before challenge, on the early and the late asthmatic response induced by a single d...
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تاریخ انتشار 2016